There are no effective therapeutics that antagonize or reverse the protein-misfolding events underpinning polyglutamine (PolyQ) disorders, including Spinocerebellar Ataxia Type-3 (SCA3).Here, we augment the proteostasis network Workstation of Drosophila SCA3 models with Hsp104, a powerful protein disaggregase from yeast, which is bafflingly absent
BackgroundFaecal microbiota transplantation (FMT) is recommended treatment for recurrent Clostridioides difficile infection and is studied as a potential modifier of other gastrointestinal and systemic disorders.Autologous FMT limits the potential risks of donor transplant material and enables prophylactic treatment.Capsulized FMT is convenient and
Small-cell lung cancer (SCLC) is an aggressive malignant cancer that is classified into four subtypes based on the expression of the following key transcription and co-transcription factors: ASCL1, NEUROD1, YAP1, and POU2F3.The protein expression levels of these key molecules may be important for the formation of SCLC characteristics in a molecular